Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin.

@article{Tan2005InteractionsBM,
  title={Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin.},
  author={Dun Tan and L. Manchester and Rosa M S{\'a}inz and Juan C Mayo and Josefa Le{\'o}n and R{\"u}diger Hardeland and Burkhard Poeggeler and Russell J Reiter},
  journal={Journal of pineal research},
  year={2005},
  volume={39 2},
  pages={185-94}
}
Interactions of melatonin and nicotinamide adenine dinucleotide (NADH) have been studied in different experimental models including NADH-promoted oxyhemoglobin oxidation, vanadate-induced NADH oxidation and paraquat-induced NADH depletion in cultured PC12 cells. Our findings indicate that melatonin preserves NADH levels under oxidative stress both in cell-free systems and in cultured PC12 cells. These interactions likely involve electron donation by melatonin and reduction of the NAD radical… CONTINUE READING

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