Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity.

@article{Xu2010InteractionsBL,
  title={Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity.},
  author={Hengyu Xu and Likai Song and Mikyung Kim and Margaret A. Holmes and Zane Kraft and George E Sellhorn and Ellis L. Reinherz and Leonidas Stamatatos and Roland K. Strong},
  journal={Journal of virology},
  year={2010},
  volume={84 2},
  pages={
          1076-88
        }
}
Human 4E10 is one of the broadest-specificity, HIV-1-neutralizing monoclonal antibodies known, recognizing a membrane-proximal linear epitope on gp41. The lipid cross-reactivity of 4E10 has been alternately suggested either to contribute to the apparent rarity of 4E10-like antibody responses in HIV infections, through elimination by B-cell tolerance mechanisms to self-antigens, or to contribute to neutralization potency by virus-specific membrane binding outside of the membrane-proximal… CONTINUE READING

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