Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity

@article{Katz1994InteractionsBL,
  title={Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity},
  author={Yeshayaku Katz and A. Weizman and C. Pick and G. Pasternak and M. Gavish},
  journal={Brain Research},
  year={1994},
  volume={646},
  pages={235-241}
}
  • Yeshayaku Katz, A. Weizman, +2 authors M. Gavish
  • Published 1994
  • Biology, Medicine
  • Brain Research
  • We examined the interactions of D,L-laudanosine, a potentially epileptogenic metabolite of the neuromuscular relaxant atracurium besylate, with gamma-aminobutyric acid (GABA) and opioid binding sites, all of which have been implicated in seizure activity. Laudanosine was almost ineffective at [3H]muscimol binding to high-affinity GABA receptors (IC50 = 100 microM). However, laudanosine displayed an inhibitory effect at the low-affinity GABA receptors labeled by [3H]bicuculline methochloride… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
    • 391
    Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures.
    • 59
    Pharmacological mechanisms of opioid analgesics.
    • 526
    Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice.
    • J. Umans, C. Inturrisi
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1981
    • 116
    U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.
    • 759