Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis.

@article{Connelly2008InteractionsBI,
  title={Interactions between integrin ligand density and cytoskeletal integrity regulate BMSC chondrogenesis.},
  author={John T Connelly and Andr{\'e}s J Garc{\'i}a and Marc Levenston},
  journal={Journal of cellular physiology},
  year={2008},
  volume={217 1},
  pages={
          145-54
        }
}
Interactions with the extracellular matrix play important roles in regulating the phenotype and activity of differentiated articular chondrocytes; however, the influences of integrin-mediated adhesion on the chondrogenesis of mesenchymal progenitors remain unclear. In the present study, agarose hydrogels were modified with synthetic peptides containing the arginine-glycine-aspartic acid (RGD) motif to investigate the effects of integrin-mediated adhesion and cytoskeletal organization on the… CONTINUE READING
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