Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.

@article{Gallagher1996InteractionsBI,
  title={Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor.},
  author={Michael T. Gallagher and Hongda Huang and Dolan B. Pritchett and David R Lynch},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 16},
  pages={9603-11}
}
Ifenprodil is an atypical noncompetitive modulator of the N-methyl-D-aspartate (NMDA) receptor (NR) which demonstrates a 140-fold preference for NR2B over NR2A subunits, although the molecular basis for this subunit specificity is unknown. We have made chimeric receptors by fusing the murine forms of NR2A (epsilon 1) and NR2B (epsilon 2) to localize the high affinity determinants of ifenprodil inhibition on the 2B subunit. Binding experiments with 125I-MK-801 implicated the region between amino… CONTINUE READING
61 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 61 extracted citations

Similar Papers

Loading similar papers…