Interactions between hypoxic and almitrine-induced vasoconstriction in the rat lung.

@article{Russell1992InteractionsBH,
  title={Interactions between hypoxic and almitrine-induced vasoconstriction in the rat lung.},
  author={P C Russell and Celia J. Emery and J. Ross Nicholl and Gwenda R Barer and Peter Howard},
  journal={Clinical science},
  year={1992},
  volume={82 3},
  pages={265-72}
}
1. To test whether almitrine might improve the arterial partial pressure of O2 in patients with chronic obstructive airways disease by improvement of ventilation-perfusion matching, we looked at the interaction between hypoxic and almitrine-induced vasoconstriction in isolated rat lungs perfused with blood at constant flow. Increases in pressure represented increases in resistance. 2. Almitrine, given in increasing doses between challenges with 2% O2, enhanced hypoxic vasoconstriction at low… CONTINUE READING

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