Interactions between human complement components factor H, factor I and C3b.

@article{Soames1997InteractionsBH,
  title={Interactions between human complement components factor H, factor I and C3b.},
  author={Candi J. Soames and Robert B Sim},
  journal={The Biochemical journal},
  year={1997},
  volume={326 ( Pt 2)},
  pages={553-61}
}
Using a microtitre plate assay, direct binding between complement factors I and H was demonstrated, and ligand blotting indicated that factor H interacts with the heavy chain of factor I. Similarly, direct C3(NH3)-factor I and C3(NH3)-factor H binding was characterized [where C3(NH3) is a form of C3 that is cleaved by factor I in the presence of factor H]. Both factor H and factor I interacted with both chains of C3(NH3) in ligand blotting. Binding reactions between all three pairs of… CONTINUE READING

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