Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)

  title={Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)},
  author={H. Dean Hosgood and Minsun Song and Chao A. Hsiung and Zhihua Yin and Xiao-Ou Shu and Zhaoming Wang and Nilanjan Chatterjee and Wei Zheng and Neil C Caporaso and Laurie A. Burdette and Meredith Yeager and Sonja I. Berndt and Maria Teresa Landi and Chien-Jen Chen and Gee-Chen Chang and Chin-Fu Hsiao and Ying Huang Tsai and Li-Hsin Chien and Kuan-Yu Chen and Ming-Shyan Huang and Wu-Chou Su and Yuh-Min Chen and Chung-Hsing Chen and Tsung-Ying Yang and Chih-Liang Wang and Jen-Yu Hung and Chien-Chung Lin and Reury Perng Perng and Chih-Yi Chen and Kun-Chieh Chen and Yao-Jen Li and Chong-Jen Yu and Yi-Song Chen and Ying-Hsiang Chen and Fang-Yu Tsai and Christopher Kim and Wei Jie Seow and Bryan A Bassig and Wei Wu and Peng Guan and Qincheng He and Yu‐Tang Gao and Qiuyin Cai and Wong-Ho Chow and Yong-Bing Xiang and Dongxin Lin and Chen Wu and Yi‐Long Wu and Min-Ho Shin and Y.-C. Hong and Keitaro Matsuo and Kexin Chen and Maria Pik Wong and Da Feng Lu and Li Jin and Jiucun Wang and Adeline L H Seow and Tangchun Wu and Hongbing Shen and Joseph F. Jr. Fraumeni and Pan‐Chyr Yang and I-Shou Chang and Baosen Zhou and Stephen J. Chanock and Nathaniel Rothman and Qing Lan},
  journal={Human Genetics},
  pages={333 - 341}
We previously carried out a multi-stage genome-wide association study (GWAS) on lung cancer among never smokers in the Female Lung Cancer Consortium in Asia (FLCCA) (6,609 cases, 7,457 controls) that identified novel susceptibility loci at 10q25.2, 6q22.2, and 6p21.32, and confirmed two previously identified loci at 5p15.33 and 3q28. Household air pollution (HAP) attributed to solid fuel burning for heating and cooking, is the leading cause of the overall disease burden in Southeast Asia, and… 

Lung cancer risk in never-smokers: An overview of environmental and genetic factors

An increased understanding of the risk factors associated with LCINS not only helps to evaluate a never-smoker’s personal risk for lung cancer, but also has important public health implications for the prevention and early detection of the disease.

Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer

A novel susceptible locus, rs420038 in SLC22A3, is revealed, which may be involved in colorectal cancer development and progression and the phenotypes of proliferation, migration, invasion, cell cycle and apoptosis of coloreCTal cancer cell were significantly affected by SLC 22A3 in vitro.

A Decade of GWAS Results in Lung Cancer

  • Y. BosséC. Amos
  • Medicine, Biology
    Cancer Epidemiology, Biomarkers & Prevention
  • 2017
GWAS results are on the edge of offering new tools for targeted screening in high-risk individuals, but more research is needed if GWAS are to pay off the investment and reach results that are medically actionable.

High risk occupational exposure and family history were risk factors in young lung cancer in Chinese

It is demonstrated that high risk occupational exposure, smoking, family history of lung cancer relatives, and age are significant risk factors for the development of Lung cancer in young Chinese.

Association between chronic obstructive pulmonary disease and PM2.5 in Taiwanese nonsmokers.

  • H. HuangF. Lin Y. Liaw
  • Medicine
    International journal of hygiene and environmental health
  • 2019

Impact of Gene–Environment Interactions on Cancer Development

An overview of the nature of gene–environment interactions is provided, and their role in human cancers is discussed, with special emphases on lung, colorectal, bladder, breast, ovarian, and prostate cancers.

Gender differences in lung cancer

Increasing knowledge of sex-differences in lung cancer pathogenesis and biology will be the background for further investigations aiming to identify genetic alterations or hormonal profiles, which could be targeted by personalized sex-based therapies.

Curbing the burden of lung cancer

Genetic risk markers may be used in risk stratification to identify subpopulations that are at a higher risk for developing lung cancer attributed to a given exposure, suggesting that precision prevention strategies may be possible in the future.