Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

@article{Murre1989InteractionsBH,
  title={Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence},
  author={C. Murre and P. McCaw and H. Vaessin and M. Caudy and D. Baltimore},
  journal={Cell},
  year={1989},
  volume={58},
  pages={537-544}
}
  • C. Murre, P. McCaw, +2 authors D. Baltimore
  • Published 1989
  • Biology, Medicine
  • Cell
  • A DNA binding and dimerization motif, with apparent amphipathic helices (the HLH motif), has recently been identified in various proteins, including two that bind to immunoglobulin enhancers (E12 and E47). We show here that various HLH proteins can bind as apparent heterodimers to a single DNA motif and also, albeit usually more weakly, as apparent homodimers. The HLH domain can mediate heterodimer formation between either daughterless, E12, or E47 (Class A) and achaete-scute T3 or MyoD (Class… CONTINUE READING
    1,547 Citations

    Figures, Tables, and Topics from this paper.

    The leucine zipper of TFE3 dictates helix-loop-helix dimerization specificity.
    • 98
    • PDF
    Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins.
    • 158
    • PDF
    DNA-mediated Folding and Assembly of MyoD-E47 Heterodimers*
    • 45
    • PDF

    References

    SHOWING 1-10 OF 40 REFERENCES
    A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
    • 2,083
    Cell-type-specific contacts to immunoglobulin enhancers in nuclei
    • 194
    • PDF
    Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.
    • 345
    The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains.
    • 306
    • PDF
    Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster.
    • 235
    Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.
    • 388
    • PDF
    DNA binding activities of three murine Jun proteins: Stimulation by Fos
    • 634
    Preferential heterodimer formation by isolated leucine zippers from fos and jun.
    • 388
    Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain
    • 355