Interactions between hepatic stellate cells and the immune system.

  title={Interactions between hepatic stellate cells and the immune system.},
  author={Jacquelyn J. Maher},
  journal={Seminars in liver disease},
  volume={21 3},
Stellate cells and immune cells are both active participants in the pathogenesis of liver disease. Interactions between these two populations are important determinants of disease outcome. Kupffer cells, neutrophils, and lymphocytes all have the potential to influence stellate cells. They produce a host of humoral mediators, including oxidants, nitric oxide, cytokines, eicosanoids, and proteinases, which can affect stellate cell proliferation, gene expression, and contractility. One important… CONTINUE READING


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