Interactions between epigenetics and metabolism in cancers

@inproceedings{Yun2012InteractionsBE,
  title={Interactions between epigenetics and metabolism in cancers},
  author={Jihye Yun and Jared L Johnson and Christin Lee Hanigan and Jason W. Locasale},
  booktitle={Front. Oncol.},
  year={2012}
}
Cancer progression is accompanied by widespread transcriptional changes and metabolic alterations. While it is widely accepted that the origin of cancer can be traced to the mutations that accumulate over time, relatively recent evidence favors a similarly fundamental role for alterations in the epigenome during tumorigenesis. Changes in epigenetics that arise from post-translational modifications of histones and DNA are exploited by cancer cells to upregulate and/or downregulate the expression… CONTINUE READING
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Oncometabolite 2hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate

  • W. Xu, H. Yang, +4 authors H S.
  • 2011
Highly Influential
4 Excerpts

IDH 1 ( R 132 H ) mutation increases murine haematopoietic progenitors and alters epigenetics

  • M. Sasaki, C. B. Knobbe, J. C. Munger, E. F. Lind, D. Brenner, A. Brustle
  • Nature
  • 2012
Highly Influential
8 Excerpts

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