Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.

@article{Larder1994InteractionsBD,
  title={Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.},
  author={Brendan Larder},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 5)},
  pages={
          951-7
        }
}
It has become apparent from recent studies that human immunodeficiency virus type 1 (HIV-1) has an enormous capacity to mutate in order to become resistant to antiretroviral agents (for a review see Larder, 1993). Monotherapy with nucleoside analogues or nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) has, without exception, resulted in the emergence of drug-resistant virus. This may take only a matter of weeks with NNRTIs (Richman et al., 1993; Saag et al., 1993), or months to… CONTINUE READING

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