Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys

@article{Schulze2012InteractionsBD,
  title={Interactions between dopamine transporter and cannabinoid receptor ligands in rhesus monkeys},
  author={David R. Schulze and F. Ivy Carroll and Lance R. McMahon},
  journal={Psychopharmacology},
  year={2012},
  volume={222},
  pages={425-438}
}
RationaleΔ9-tetrahydrocannabinol (Δ9-THC) modifies dopamine efflux. However, the extent to which cannabinoid and dopamine drugs modify each other’s behavioral effects has not been fully established.ObjectivesThis study examined dopamine releasers and/or transport inhibitors alone and in combination with cannabinoids in two drug discrimination assays.MethodsExperimentally and pharmacologically experienced rhesus monkeys (n = 5) discriminated Δ9-THC (0.1 mg/kg i.v.) from vehicle while responding… Expand
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