Interactions between diltiazem and isoflurane. An in vitro investigation in isolated guinea pig atria.


Maximum force of contraction of paced, isolated guinea pig atria was measured in three groups. Atria from animals in group 1 were exposed to isoflurane for 10 min. In group 2, atria were exposed to diltiazem 35 nmol litre-1 alone and in group 3 atria were pre-treated with diltiazem 35 nmol litre-1 before exposure to isoflurane. Maximum depression of… (More)


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