Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.

  title={Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.},
  author={Iliyan D Iliev and Vincent A. Funari and Kent D. Taylor and Quoclinh Nguyen and Christopher N. Reyes and Samuel P Strom and Jordan L Brown and Courtney A Becker and Phillip R. Fleshner and Marla J Dubinsky and Jerome I. Rotter and Hanlin L. Wang and Dermot Patrick McGovern and Gordon D Brown and David M Underhill},
  volume={336 6086},
The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the mammalian gut contains a rich fungal community that interacts with the immune system through the innate immune receptor Dectin-1. Mice lacking Dectin-1 exhibited increased susceptibility to chemically induced colitis, which was the result of altered responses to indigenous fungi. In humans, we identified a polymorphism in the gene for Dectin-1… CONTINUE READING
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