Interactions between cocaine and (-)-DS 121: studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain.

@article{Koch1997InteractionsBC,
  title={Interactions between cocaine and (-)-DS 121: studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain.},
  author={Sabrina Koch and Montford F. Piercey and Matthew Peter Galloway and Kjell Anders Ivan Svensson},
  journal={European journal of pharmacology},
  year={1997},
  volume={319 2-3},
  pages={
          173-80
        }
}
(-)-DS 121 [S-(-)-3-(3-cyanophenyl)-N-n-propyl piperidine], a dopamine autoreceptor preferring antagonist, has been shown to stimulate locomotor activity and induce conditioned place preference. However, the drug fails to facilitate intracranial self-stimulation or substitute for cocaine in cueing experiments, and it blocks cocaine self-administration. In the present study using 2-deoxyglucose autoradiography, (-)-DS 121 (at 50 but not 15 mg/kg i.p.) significantly and selectively increased… CONTINUE READING