Interactions between circulating peptides and the central nervous system in hemodynamic regulation.

@article{Sander1989InteractionsBC,
  title={Interactions between circulating peptides and the central nervous system in hemodynamic regulation.},
  author={Gary E. Sander and R F Lowe and Michael B Given and Thomas D. Giles},
  journal={The American journal of cardiology},
  year={1989},
  volume={64 6},
  pages={44C-50C}
}
Enkephalins and endothelins are endogenous peptides, which, at least at pharmacologic doses, produce complex hemodynamic responses after intravenous administration. The enkephalins, when injected into conscious animal models and humans, increase blood pressure, heart rate and minute ventilation. This response occurs by activation of specific opiate receptors located outside the bloodbrain barrier; the actual mechanism involves an increase in adrenergic autonomic nervous system tone and a… CONTINUE READING