Interactions between buprenorphine and antiretrovirals. II. The protease inhibitors nelfinavir, lopinavir/ritonavir, and ritonavir.

@article{McCanceKatz2006InteractionsBB,
  title={Interactions between buprenorphine and antiretrovirals. II. The protease inhibitors nelfinavir, lopinavir/ritonavir, and ritonavir.},
  author={Elinore F McCance-Katz and David E. Moody and Patrick F. Smith and Gene D. Morse and Gerald Friedland and Patricia A Pade and Jennifer R Baker and Anika Ah Alvanzo and Peter Jatlow and Petrie M. Rainey},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2006},
  volume={43 Suppl 4},
  pages={S235-46}
}
We examined drug interactions between buprenorphine, an opioid partial agonist available by prescription for treatment of opioid dependence, and the protease inhibitors (PIs) nelfinavir (NFV), ritonavir (RTV), and lopinavir/ritonavir (LPV/R). Opioid-dependent, buprenorphine/naloxone-maintained, human immunodeficiency virus (HIV)-negative volunteers (n=10 per PI) participated in 24-h pharmacokinetic studies, before and after administration of each PI. Symptoms of opiate withdrawal and excess… CONTINUE READING

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