Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral entry into the central nervous system.

@article{Romero2000InteractionsBB,
  title={Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral entry into the central nervous system.},
  author={Ignacio Andres Romero and Marie Christine Pr{\'e}vost and Emmanuelle Perret and Pete Adamson and Jessica Greenwood and Pierre Olivier Couraud and S. G. Ozden},
  journal={Journal of virology},
  year={2000},
  volume={74 13},
  pages={6021-30}
}
Human T-cell leukemia virus type 1 (HTLV-1) is associated with a variety of clinical manifestations, including tropical spastic paraparesis or HTLV-1-associated myelopathy (TSP/HAM). Viral detection in the central nervous system (CNS) of TSP/HAM patients demonstrates the ability of HTLV-1 to cross the blood-brain barrier (BBB). To investigate viral entry into the CNS, rat brain capillary endothelial cells were exposed to human lymphocytes chronically infected by HTLV-1 (MT2), to lymphocytes… CONTINUE READING

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