Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis.

@article{Drexler2010InteractionsBA,
  title={Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis.},
  author={Berthold Drexler and Bernd Antkowiak and Horst Thiermann and Thomas Banjo Seeger and Christian Grasshoff},
  journal={Toxicology letters},
  year={2010},
  volume={198 3},
  pages={
          342-7
        }
}
General anaesthesia is an important measure in the treatment of patients suffering from organophosphorus intoxication. The intravenous anaesthetic etomidate seems to be well suited for this purpose because of its stable haemodynamics. Here we raise the question whether the anaesthetic properties of etomidate are altered by cholinergic overstimulation and by the cholinergic antagonist atropine. As the neocortex and spinal cord mediate unconsciousness and immobility, organotypic cultures from… CONTINUE READING
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