Interactions between asynchronous release and short-term plasticity in the nucleus accumbens slice.

@article{Hjelmstad2006InteractionsBA,
  title={Interactions between asynchronous release and short-term plasticity in the nucleus accumbens slice.},
  author={Gregory O Hjelmstad},
  journal={Journal of neurophysiology},
  year={2006},
  volume={95 3},
  pages={
          2020-3
        }
}
  • G. Hjelmstad
  • Published 1 March 2006
  • Biology, Psychology
  • Journal of neurophysiology
Glutamate synapses in the nucleus accumbens (NAc) display asynchronous release in response to trains of stimulation. However, it is unclear what role this asynchronous release plays in synaptic transmission in this nucleus. This process was studied, specifically looking at the interaction between short-term depression and asynchronous release. These results indicate that synchronous and asynchronous release do not compete for a depleted readily releasable pool of vesicles. 
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Integration of Asynchronously Released Quanta Prolongs the Postsynaptic Spike Window
TLDR
It is demonstrated that glutamatergic terminals in PVN exhibit asynchronous release, which is important in generating large postsynaptic depolarizations and prolonged spiking in response to brief, high-frequency bursts of presynaptic activity.
Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.
TLDR
It is verified that a number of manipulations of Ca(2+) handling and influx selectively alter asynchronous release relative to phasic transmitter release during action potential trains in cultured excitatory autaptic hippocampal neurons, and suggested the possibility of differential control of synchronous versus asynchronous vesicle release.
Short-term synaptic depression can increase the rate of information transfer at a release site
TLDR
A mathematically tractable model of both synchronous spike-evoked release and asynchronous release is proposed that permits us to quantify the information conveyed by a synapse and shows that dopamine, by controlling asynchronous release in corticostriatal synapses, increases the synaptic information efficacy in nucleus accumbens.
Developmental reduction of asynchronous GABA release from neocortical fast-spiking neurons.
TLDR
Recording from fast-spiking interneurons and pyramidal cells in prefrontal cortical slices obtained from juvenile and adult rats revealed that the AR strength was stronger at juvenile but weaker in adult, possibly resulting from changes in presynaptic Ca(2+) dynamics.
Vesicles derived via AP-3 dependent recycling contribute to asynchronous release and influence information transfer
TLDR
During trains of stimulations, synchronous and asynchronous neurotransmitter release contributes to the precision of action potential firing and Lack of asynchronous release decreases the capacity of synaptic information transfer and renders synaptic communication less reliable in response to natural stimulus patterns.
Shunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development
TLDR
This work modeled both phasic and asynchronous synaptic transmission in early development to study the impact of activity-dependent noise and short-term plasticity on the synaptic gain and found that asynchronous release can regulate the information flow at synapses and its impact can be flexibly modulated by the membrane conductance.
Prolonged synaptic currents increase relay neuron firing at the developing retinogeniculate synapse.
TLDR
Fluorescence measurements of presynaptic calcium transients suggest that prolonged residual calcium contributes to both glutamate spillover and asynchronous release, and indicate that, during development, far more RGCs contribute to relay neuron firing than would be expected based on predictions from anatomy alone.
Asynchronic transmission in the CA3–CA1 hippocampal synapses in the neurological mutant taiep rat
TLDR
Findings in hippocampal circuitry suggest that, in taiep, the asynchronous evoked activity represents a rather generalized phenotype of the glutamatergic synapses and that EPSCASYN seems to be determined by presynaptic alterations.
Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult.
TLDR
The portrait of excitatory synapses and intrinsic properties of medium spiny neurons of the nucleus accumbens of the mesocorticolimbic system is presented, finding that intrinsic neuronal excitability decreased over development.
Developmental Mechanisms for Suppressing the Effects of Delayed Release at the Endbulb of Held
TLDR
Endbulbs from CBA/CaJ mice aged P6–P49 showed prominent delayed release when driven at physiologically relevant rates, and Enhancement of delayed release using strontium was correlated with lower firing probability in current clamp and smaller synchronous EPSCs in voltage clamp, and EGTA-AM had the opposite effects.
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