Interactions between apolipoprotein E and apolipoprotein(a) in patients with late-onset Alzheimer disease.

@article{Mooser2000InteractionsBA,
  title={Interactions between apolipoprotein E and apolipoprotein(a) in patients with late-onset Alzheimer disease.},
  author={Vincent E. Mooser and Nicole Helbecque and Judith Miklossy and Santica M. Marcovina and Pascal Nicod and Philippe Amouyel},
  journal={Annals of internal medicine},
  year={2000},
  volume={132 7},
  pages={533-7}
}
The apolipoprotein E (apoE) E4 isoform has been implicated in the pathogenesis of Alzheimer disease (1). Not all carriers of the apoE 4 allele develop Alzheimer disease; therefore, additional risk factors probably exist (2). The very-low-density lipoprotein receptor (3) and the low-density lipoprotein receptor-related protein (4) (a receptor that is expressed by human neurons and internalizes apoE [5]) have been associated with Alzheimer disease and with defects in neuronal migration (6… CONTINUE READING

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