Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats.

@article{Heras2007InteractionsBA,
  title={Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats.},
  author={Natalia de las Heras and Marta Ruiz-Ortega and Mar{\'i}a Miana and M{\'o}nica Rup{\'e}rez and David Sanz-Rosa and Paloma Aragoncillo and Sergio A. Mezzano and Victoria Cachofeiro and J. Puente Egido and Vicente Lahera},
  journal={Journal of hypertension},
  year={2007},
  volume={25 3},
  pages={
          629-38
        }
}
OBJECTIVE The aim of the present study was to investigate possible inter-relationships between connective tissue growth factor (CTGF) and aldosterone in vascular and renal damage associated with hypertension. METHOD Spontaneously hypertensive rats (SHR) were treated with two doses (100 and 30 mg/kg per day) of the mineralocorticoid receptor antagonist eplerenone, or with antihypertensive therapy (HHR) (20 mg/kg per day hydralazine + 7 mg/kg per day hydrochlorothiazide + 0.15 mg/kg per day… CONTINUE READING
BETA

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