Corpus ID: 31870671

Interactions between alcohol and gastric metabolizing enzymes: practical implications.

  title={Interactions between alcohol and gastric metabolizing enzymes: practical implications.},
  author={Juan Caballer{\'i}a},
  journal={Clinical therapeutics},
  volume={13 4},
It has been demonstrated recently that some portion of ingested alcohol does not enter the systemic circulation and is not retained in the gastrointestinal tract; instead, gastric oxidation or first-pass metabolism of ethanol occurs in the stomach, catalyzed by gastric alcohol dehydrogenase. First-pass metabolism of ethanol is minimal in the fasting state; it is lower in women than in men, and in alcoholics than in nonalcoholics; and it is abolished in patients after subtotal gastrectomy. In… Expand
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