Corpus ID: 31870671

Interactions between alcohol and gastric metabolizing enzymes: practical implications.

@article{Caballera1991InteractionsBA,
  title={Interactions between alcohol and gastric metabolizing enzymes: practical implications.},
  author={Juan Caballer{\'i}a},
  journal={Clinical therapeutics},
  year={1991},
  volume={13 4},
  pages={
          511-20
        }
}
It has been demonstrated recently that some portion of ingested alcohol does not enter the systemic circulation and is not retained in the gastrointestinal tract; instead, gastric oxidation or first-pass metabolism of ethanol occurs in the stomach, catalyzed by gastric alcohol dehydrogenase. First-pass metabolism of ethanol is minimal in the fasting state; it is lower in women than in men, and in alcoholics than in nonalcoholics; and it is abolished in patients after subtotal gastrectomy. In… Expand
Metabolic interactions between alcohol, the liver and the gastrointestinal tract.
TLDR
This thesis examines the metabolic interactions between alcohol and the liver and gastrointestinal tract and concludes that the colorimetric technique described for assaying gastric alcohol dehydrogenase activity can offer significant advantages over conventional methods. Expand
Effect of Cimetidine on the Pharmacokinetics of Alcohol in Social and Chronic Drinkers
TLDR
Clinicians should counsel patients about the possibility of enhanced impairment resulting from concurrent administration of these 2 drugs, as chronic drinkers who drink after cimetidine administration will have higher concentrations of alcohol faster than social drinkers. Expand
The consequences of imbibing alcohol in the absence of adequate nutrition: the salt and water hypothesis.
TLDR
The salt and water hypothesis integrates the biochemical findings from the current alcohol literature and proposes a mechanism by which alcohol consumption prior to food intake may cause a transient alteration in the functioning of the hypothalamic-pituitary-adrenal axis due to an alcohol-induced impairment in electrolyte regulation. Expand
The effect of a moderate level of white wine consumption on the hypothalamic–pituitary–adrenal axis before and after a meal
TLDR
It was concluded that moderate white wine consumption may promote a transient alteration in the functioning of the HPA axis when alcohol is consumed alone under fasting conditions only. Expand
Alcohol consumption in the absence of adequate nutrition may lead to activation of the glyoxylate cycle in man.
TLDR
The possibility that alcohol consumption in the absence of adequate nutrition after an extended period of time may lead to activation of the glyoxylate cycle, an energy pathway associated with the conversion of fat into carbohydrate which until recently was thought to only exist in plants and bacteria, is highlighted. Expand
Molecular biological aspects of alcohol-induced liver disease.
TLDR
This review focuses on the advances made in studies of two important enzymes responsible for alcohol metabolism, alcohol dehydrogenase and aldehyde dehydrogenases, as well as the investigation of the proinflammatory and profibrogenic cytokines involved in the process of hepatic fibrogenesis. Expand
Main ethanol metabolizing alcohol dehydrogenases (ADH I and ADH IV): biochemical functions and the physiological manifestation
TLDR
Recent data suggest a correlation between the activity of ADH I in some organs and fine physiological processes including behavior regulation and craving for alcohol in albino rats. Expand
Effect on plasma insulin and plasma glucose of consuming white wine alone after a meal.
TLDR
The data showed a significant alcohol-induced decrease in the level of plasma insulin and a nonsignificant trend for a decrease in plasma glucose concentration in all participants after 15 g of alcohol had been consumed alone after a meal. Expand
Sex- and strain-related differences in first-pass alcohol metabolism in mice.
TLDR
The results provide evidence for first-pass alcohol metabolism in mice and show the effects of sex and strain on gastric oxidation of alcohol. Expand
Changes in blood alcohol levels as a function of alcohol concentration and repeated alcohol exposure in adult female rats: potential risk factors for alcohol-induced fetal brain injury.
TLDR
The results suggest that alcohol concentration and repeated alcohol exposure can influence BAC and, as such, are important risk factors to be considered in the appraisal of alcohol-induced fetal brain injuries. Expand
...
1
2
...