Interactions between a Pore-Blocking Peptide and the Voltage Sensor of the Sodium Channel: An Electrostatic Approach to Channel Geometry

@article{French1996InteractionsBA,
  title={Interactions between a Pore-Blocking Peptide and the Voltage Sensor of the Sodium Channel: An Electrostatic Approach to Channel Geometry},
  author={Robert J. French and Elzbieta Prusak-Sochaczewski and Gerald W Zamponi and Stefan Becker and A S Kularatna and Richard Horn},
  journal={Neuron},
  year={1996},
  volume={16},
  pages={407-413}
}
Few experimental data illuminate the relationship between the molecular structures that mediate ion conduction through voltage-dependent ion channels and the structures responsible for sensing transmembrane voltage and controlling gating. To fill this void, we have used a strongly cationic, mutated mu-conotoxin peptide, which only partially blocks current through voltage-dependent sodium channels, to study voltage-dependent activation gating in both bound and unbound channels. When the peptide… CONTINUE READING

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