Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children.

Abstract

CONTEXT The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been associated with risk of developing type 2 diabetes mellitus (DM), possibly by decreasing insulin secretion. Small for gestational age (SGA) birth has been associated with type 2 DM in later life. Growth hormone (GH) treatment reduces insulin sensitivity and increases… (More)
DOI: 10.1111/j.1365-2265.2009.03635.x

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