Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.

@article{Jandus2014InteractionsBS,
  title={Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.},
  author={Camilla Jandus and Kayluz Frias Boligan and Obinna Chijioke and He Liu and Meike Dahlhaus and Thomas D{\'e}moulins and Christoph Schneider and Marc Wehrli and Robert Emil Hunger and Gabriela M. Baerlocher and Hans-Uwe Simon and Pedro Romero and Christian M{\"u}nz and Stephan von Gunten},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 4},
  pages={
          1810-20
        }
}
Alteration of the surface glycosylation pattern on malignant cells potentially affects tumor immunity by directly influencing interactions with glycan-binding proteins (lectins) on the surface of immunomodulatory cells. The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates. Here, we found that the presence of Siglec-9 defined a subset of cytotoxic NK cells with a mature… CONTINUE READING

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