Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth.

@article{Cho2011InteractionsBS,
  title={Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth.},
  author={S. W. Cho and Sungwook Kwak and Thomas E. Woolley and M R Lee and Eun-Jung Kim and Ruth E. Baker and Hee-Jin Kim and Jeon-Soo Shin and Cheryll Tickle and Philip K. Maini and H S Jung},
  journal={Development},
  year={2011},
  volume={138 9},
  pages={1807-16}
}
Each vertebrate species displays specific tooth patterns in each quadrant of the jaw: the mouse has one incisor and three molars, which develop at precise locations and at different times. The reason why multiple teeth form in the jaw of vertebrates and the way in which they develop separately from each other have been extensively studied, but the genetic mechanism governing the spatial patterning of teeth still remains to be elucidated. Sonic hedgehog (Shh) is one of the key signaling… CONTINUE READING
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Missense mutations in IHH impair Indian Hedgehog signaling in C 3 H 10 T 1 / 2 cells : Implications for brachydactyly type A 1 , and new targets for Hedgehog signaling

S. Guo, J. Zhou, +4 authors C. Lin
Cell Mol . Biol . Lett . • 2010

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