Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis.

@article{Novick2006InteractionsBR,
  title={Interactions between Rabs, tethers, SNAREs and their regulators in exocytosis.},
  author={Peter Jay Novick and Martina Medkov{\'a} and Guizhen Dong and Alex H. Hutagalung and Katharina Reinisch and Bianka L. Grosshans},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 5},
  pages={
          683-6
        }
}
Sec2p is the exchange factor that activates Sec4p, the Rab GTPase controlling the final stage of the yeast exocytic pathway. Sec2p is recruited to secretory vesicles by Ypt32-GTP, a Rab controlling exit from the Golgi. Sec15p, a subunit of the octameric exocyst tethering complex and an effector of Sec4p, binds to Sec2p on secretory vesicles, displacing Ypt32p. Sec2p mutants defective in the region 450-508 amino acids bind to Sec15p more tightly. In these mutants, Sec2p accumulates in the… CONTINUE READING
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