Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in ratsin vivo

  title={Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in ratsin vivo},
  author={Kazuhiko Watanabe},
  journal={Journal of Anesthesia},
In this study, combined neuromuscular blocking effects of ORG9426 with other non-depolarizing neuromuscular blocking agents were investigated. About 20% steady state neuromuscular block was established by a continuous infusion of one of 6 neuromuscular blocking agents (ORG9426, vecuronium, pancuronium, pipecuronium, d-tubocurarine and metocurine). Then 1/7 of the ED50 of ORG9426 or one of other neuromuscular blocking agents was administered in a single injection, and the increase in the… Expand
Pharmacoeconomics and Pharmacodynamic Interactions of Rocuronium and Pancuronium
The combination of P and R provides rapid and smooth intubation with minimal hemodynamic changes at a reasonably priced cost. Expand


Potentiation of Neuromuscular Blockade in Man Produced by Combinations of Pancuronium and Metocurine or Pancuronium and d‐Tubocurarine
Combining pancuronium with dTc or with metocurine can provide surgical relaxation or ideal conditions for endotracheal intubation with smaller amounts of each drug than would be anticipated if their effects were simply additive. Expand
The neuromuscular effects of ORG9426 in patients receiving balanced anesthesia.
In searching for a nondepolarizing muscle relaxant with intermediate duration but more rapid onset of action than the presently available compounds, the neuromuscular and circulatory effects ofExpand
Quantitative Examination of the Interaction of Competitive Neuromuscular Blocking Agents on the Indirectly Elicited Muscle Twitch
It is demonstrated that the deviation from simple additivity seen in vivo persists when examined in a system free from artifacts associated with uptake and distribution in the whole organism. Expand
Vecuronium and d‐Tubocurarine Combination: Potentiation of Effect
C cumulative dose-response curves were constructed and showed the combination of vecuronium plus d-tubocurarine to be significantly more potent than would be expected from a simple additive effect of the individual drugs given alone. Expand
Interaction among Agents that Block End‐plate Depolarization Competitively
The influence of gallamine, metocurine, pancuronium, and tubocurarine on depolarization of a mammalian muscle end-plate region was examined to determine whether the antagonists given in combinationExpand
Interactions between tubocurarine, pancuronium and alcuronium demonstrated in the rat phrenic nerve-hemidiaphragm preparation.
Mixtures of tubocurarine and pancuronium and alcuronium were found to have a more potent effect than the additive effects of the individual agents when given alone, that is, mixtures were synergistic. Expand
Dose-response studies with pancuronium, vecuronium and their combination.
Pancuronium, vecuronium and a combination of these were administered in an incremental fashion to study any potentiation of effect with the combination of the two relaxants. The ED95 (dose producingExpand
Time course of action of combinations of vecuronium and pancuronium
Combinations of vecuronium and pancuronium have no advantage over the individual drugs, and the duration of clinicul relaxation was 25 minutes with veCuronium, and increased as the proportion of Pancuronium in the niixturc increased, being 56 minutes with pancuronia 0.I mg/kg. Expand
Dose-Response Curves for Alcuronium and Pancuronium Alone and in Combination
  • C. Shanks
  • Medicine
  • Anaesthesia and intensive care
  • 1982
Simultaneous administration of pancuronium and alcuronium was used in surgical patients during nitrous oxide — narcotic — barbiturate anaesthesia in order to determine the intensity of neuromuscularExpand
Prejunctional and Postjunctional Cholinoceptors at the Neuromusclar Junction
  • W. Bowman
  • Medicine
  • Anesthesia and analgesia
  • 1980
The clearest indications that the transmission mechanism is more complex than was hitherto supposed may be derived from a consideration of the phenomena of tetanic fade and its electrophysiologic counterparts, tetanic run-down of end plate potential. Expand