Interactions between Neuronal Nicotinic Acetylcholine Receptors, N-Methyl-D-Aspartate Receptors and β-amyloid in the Brain of Genetically Modified Mice - Implications for Alzheimer’s disease

Abstract

The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer’s disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid β-peptide (Aβ) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial… (More)

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