Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice

@article{Bredeloux2006InteractionsBN,
  title={Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice},
  author={P. Bredeloux and J. Costentin and I. Dubuc},
  journal={Behavioural Brain Research},
  year={2006},
  volume={175},
  pages={399-407}
}
  • P. Bredeloux, J. Costentin, I. Dubuc
  • Published 2006
  • Chemistry, Medicine
  • Behavioural Brain Research
  • The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain. We investigated whether these effects are mediated by the opioid receptors. In the hot plate test, the NT receptors agonist NT1 (N(alpha)Me-Arg-Lys-Pro-Trp-Tle-Leu), s.c. injected (0.3-3 mg/kg), increased paw licking and jump latencies. These effects were inhibited by the NTS2 antagonist levocabastine (2.5 mg/kg, i.p.) but not by the selective NTS1… CONTINUE READING
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