Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice
@article{Bredeloux2006InteractionsBN, title={Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice}, author={P. Bredeloux and J. Costentin and I. Dubuc}, journal={Behavioural Brain Research}, year={2006}, volume={175}, pages={399-407} }
The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain. We investigated whether these effects are mediated by the opioid receptors. In the hot plate test, the NT receptors agonist NT1 (N(alpha)Me-Arg-Lys-Pro-Trp-Tle-Leu), s.c. injected (0.3-3 mg/kg), increased paw licking and jump latencies. These effects were inhibited by the NTS2 antagonist levocabastine (2.5 mg/kg, i.p.) but not by the selective NTS1… CONTINUE READING
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References
SHOWING 1-10 OF 30 REFERENCES
Potent Spinal Analgesia Elicited through Stimulation of NTS2 Neurotensin Receptors
- Medicine
- The Journal of Neuroscience
- 2005
- 62
- PDF
Potentiation by thiorphan and bestatin of the naloxone-insensitive analgesic effects of neurotensin and neuromedin n
- Chemistry, Medicine
- Neurochemistry International
- 1988
- 48
Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1981
- 104
Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin
- Chemistry, Medicine
- The Journal of Neuroscience
- 1999
- 110
- PDF
The partial agonist properties of levocabastine in neurotensin-induced analgesia.
- Chemistry, Medicine
- European journal of pharmacology
- 1999
- 40
Opioid-induced release of neurotensin in the periaqueductal gray matter of freely moving rats
- Chemistry, Medicine
- Brain Research
- 1997
- 23
Dissociated effects of inhibitors of enkephalin-metabolising peptidases or naloxone on various nociceptive responses.
- Chemistry, Medicine
- European journal of pharmacology
- 1986
- 56
Comparative Antipsychotic Profiles of Neurotensin and a Related Systemically Active Peptide Agonist
- Biology, Medicine
- Peptides
- 1997
- 46
Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1979
- 167
- PDF