Interactions between N-methyl-D-aspartate receptor antagonists and the discriminative stimulus effects of morphine in rats.

Abstract

NMDA receptor antagonists have previously been reported to alter some pharmacological and behavioral effects of acute and chronic opioid administration. The present study assessed the interactions of NMDA antagonists with the discriminative stimulus properties of morphine. Adult male Long Evans rats were trained to discriminate 3.2 mg/kg of s.c. morphine… (More)

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