Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines.

@article{Boven2000InteractionsBH,
  title={Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines.},
  author={Leonie A. Boven and Jeena Middel and Esther C W Breij and Diana Schotte and J. C. Barendrecht Verhoef and Carl A Soderland and Hans SLM Nottet},
  journal={Journal of neurovirology},
  year={2000},
  volume={6 5},
  pages={382-9}
}
The presence of perivascular monocytic infiltration is a major hallmark of HIV-1-associated dementia. Since CC chemokines are chemoattractant cytokines that are able to attract T cells and monocytes/macrophages to sites of inflammation, and since infiltrating monocytes/macrophages remain in close contact with the brain endothelium, we investigated whether interactions between HIV-1-infected macrophages and brain endothelium result in an altered chemokine production. We found an increased mRNA… CONTINUE READING

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