Interactions between Glucocorticoid Treatment and Cis-Regulatory Polymorphisms Contribute to Cellular Response Phenotypes

@inproceedings{Maranville2011InteractionsBG,
  title={Interactions between Glucocorticoid Treatment and Cis-Regulatory Polymorphisms Contribute to Cellular Response Phenotypes},
  author={Joseph C. Maranville and Francesca Luca and Allison L Richards and Xiaoquan Wen and David B. Witonsky and Shaneen S. Baxter and Matthew Stephens and Anna Maria Di Rienzo},
  booktitle={PLoS genetics},
  year={2011}
}
Glucocorticoids (GCs) mediate physiological responses to environmental stress and are commonly used as pharmaceuticals. GCs act primarily through the GC receptor (GR, a transcription factor). Despite their clear biomedical importance, little is known about the genetic architecture of variation in GC response. Here we provide an initial assessment of variability in the cellular response to GC treatment by profiling gene expression and protein secretion in 114 EBV-transformed B lymphocytes of… CONTINUE READING
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A Catalog of Published Genome-Wide Association Studies.: Available at: www.genome.gov/gwastudies

  • LA JHHindorff, PN Hall, JP Mehta, TA Manolio
  • 2011
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