Interactions between GSK3β and amyloid genes explain variance in amyloid burden.

@article{Hohman2014InteractionsBG,
  title={Interactions between GSK3β and amyloid genes explain variance in amyloid burden.},
  author={Timothy J. Hohman and Mary Ellen Koran and Tricia A. Thornton-Wells},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 3},
  pages={460-5}
}
The driving theoretical framework of Alzheimer's disease (AD) has been built around the amyloid-β (Aβ) cascade in which amyloid pathology precedes and drives tau pathology. Other evidence has suggested that tau and amyloid pathology may arise independently. Both lines of research suggest that there may be epistatic relationships between genes involved in amyloid and tau pathophysiology. In the current study, we hypothesized that genes coding glycogen synthase kinase 3 (GSK-3) and comparable tau… CONTINUE READING