Interactions between DNA damage, repair, and transcription.

  title={Interactions between DNA damage, repair, and transcription.},
  author={Andriy Khobta and Bernd Epe},
  journal={Mutation research},
  volume={736 1-2},
This review addresses a variety of mechanisms by which DNA repair interacts with transcription and vice versa. Blocking of transcriptional elongation is the best studied of these mechanisms. Transcription recovery after damage therefore has often been used as a surrogate marker of DNA repair in cells. However, it has become evident that relationships between DNA damage, repair, and transcription are more complex due to various indirect effects of DNA damage on gene transcription. These include… CONTINUE READING

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