Interactions between DNA-bound trimers of the yeast heat shock factor.

@article{Bonner1994InteractionsBD,
  title={Interactions between DNA-bound trimers of the yeast heat shock factor.},
  author={Joseph J. Bonner and Clinton E. Ballou and Donna Lee Fackenthal},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 1},
  pages={501-8}
}
The heat shock transcription factor (HSF) is a trimer that binds to DNA containing inverted repeats of the sequence nGAAn. HSF can bind DNA with the sequence nGAAnnTTCn or with the sequence nTTCnnGAAn, with little preference for either sequence over the other. However, (nGAAnnTTCn)2 is considerably less active as a heat shock response element (HSE) than is (nTTCnnGAAn)2. The electrophoretic mobilities of DNA-protein complexes and chemical cross-linking between protein monomers indicate that the… CONTINUE READING