Interactions between Clostridium perfringens enterotoxin and claudins.

  title={Interactions between Clostridium perfringens enterotoxin and claudins.},
  author={Susan L. Robertson and Bruce A McClane},
  journal={Methods in molecular biology},
Clostridium perfringens enterotoxin (CPE), a single polypeptide of approximately 35 kDa in size, is -associated with type A food poisoning and such non-foodborne gastrointestinal diseases as antibiotic-associated diarrhea and sporadic diarrhea. CPE action begins with binding of the toxin to a claudin -receptor, forming a ∼90 kDa small complex that then rapidly oligomerizes into a hexamer of ∼450 kDa termed CH-1 (CPE hexamer-1). CH-1 is essentially a pore through which calcium gains entry to the… CONTINUE READING