Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.

Abstract

The CXCR4/CXCL12 axis plays an important role in cell locomotion and metastasis in many cancers. In this study, we hypothesized that the CXCR4/CXCL12 axis promotes migration and invasion of canine hemangiosarcoma (HSA) cells. Transcriptomic analysis across 12 HSA cell lines and 58 HSA whole tumour tissues identified heterogeneous expression of CXCR4 and… (More)
DOI: 10.1111/vco.12165

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Cite this paper

@article{Im2017InteractionsBC, title={Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma.}, author={Kiegon Im and A J Graef and Meghan E. Breen and Kerstin Lindblad-Toh and J F Modiano and J-H Kim}, journal={Veterinary and comparative oncology}, year={2017}, volume={15 2}, pages={315-327} }