Interactions between CBP, NF-kappaB, and CREB in the lungs after hemorrhage and endotoxemia.

@article{Shenkar2001InteractionsBC,
  title={Interactions between CBP, NF-kappaB, and CREB in the lungs after hemorrhage and endotoxemia.},
  author={Robert Shenkar and Ho Kee Yum and John J. Arcaroli and John G. Kupfner and Edward Abraham},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={281 2},
  pages={L418-26}
}
The transcriptional regulatory factor nuclear factor (NF)-kappaB has a central role in modulating expression of proinflammatory mediators that are important in acute lung injury. In vitro studies have shown that competition between NF-kappaB and cAMP response element binding protein (CREB) for binding to the coactivator CREB-binding protein (CBP) is important in regulating transcriptional activity of these factors. In the present study, we examined in vivo interactions between CBP, CREB, and NF… CONTINUE READING