Interactions between β2-syntrophin and a family of microtubule-associated serine/threonine kinases

  title={Interactions between β2-syntrophin and a family of microtubule-associated serine/threonine kinases},
  author={Carey N Lumeng and Stephanie N Phelps and Gregory E. Crawford and Paul D. Walden and Kate F. Barald and Jeffrey S. Chamberlain},
  journal={Nature Neuroscience},
A screen for proteins that interact with β2-syntrophin led to the isolation of MAST205 (microtubule-associated serine/threonine kinase-205 kD) and a newly identified homologue, SAST (syntrophin-associated serine/threonine kinase). Binding studies showed that β2-syntrophin and MAST205/SAST associated via a PDZ–PDZ domain interaction. MAST205 colocalized with β2-syntrophin and utrophin at neuromuscular junctions. SAST colocalized with syntrophin in cerebral vasculature, spermatic acrosomes and… CONTINUE READING


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