Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients : a comprehensive review

@inproceedings{Bharate2010InteractionsAI,
  title={Interactions and incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients : a comprehensive review},
  author={Sandip B Bharate and Amrita Narayan Bajaj},
  year={2010}
}
Studies of active drug/excipient compatibility represent an important phase in the preformulation stage of the development of all dosage forms. The potential physical and chemical interactions between drugs and excipients can affect the chemical nature, the stability and bioavailability of drugs and, consequently, their therapeutic efficacy and safety. The present review covers the literature reports of interaction and incompatibilities of commonly used pharmaceutical excipients with different… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 130 references

Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques

  • G Bruni, V Berbenni, C Milanese, A Girella, A Marini
  • J. Therm. Anal. Cal.,
  • 2010

Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes

  • MA Moyano, AM Broussalis, AI Segall
  • 2010

Thermal decomposition kinetics and compatibility studies of primaquine under isothermal and non-isothermal conditions

  • CD Bertol, AP Cruz, HK Stulzer, FS Murakami, MAS Silva
  • J. Therm. Anal. Calorim.,
  • 2010

Compatibility study between chlorpropamide and excipients in their physical mixtures

  • FD Freire, CFS Aragao, TFAdLe Moura, R FN
  • J. Therm. Anal. Calorim
  • 2009

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