Interactions and effects of aminophylline, terbutaline sulfate and verapamil on calcium transport across rat diaphragm.

@article{Kanj1987InteractionsAE,
  title={Interactions and effects of aminophylline, terbutaline sulfate and verapamil on calcium transport across rat diaphragm.},
  author={N A Kanj and R E Ayash and Ziyad M.B. Ghazzal and G M Saadeh and Camille F. Nassar},
  journal={General pharmacology},
  year={1987},
  volume={18 4},
  pages={
          437-9
        }
}
The effect of terbutaline sulfate on calcium transport across muscle strips isolated from rat diaphragms, and its effect on this process when used in combination with aminophylline was investigated using labelled calcium in a two-compartment system. The results show that terbutaline sulfate causes a dose-dependent increase in intracellular calcium concentration which reached saturation at a terbutaline sulfate concentration of 2 ng/ml. The inclusion of both aminophylline and terbutaline sulfate… Expand
3 Citations
Digoxin-stimulated calcium transport across rat diaphragm interactions with aminophylline and verapamil.
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The effect of increasing calcium concentration in the presence of digoxin and digoxin plus aminophylline in the incubation medium, showed a nonsaturable linear relationship between calcium concentration and intracellular calcium accumulation. Expand
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By enhancing the contractility of the diaphragm, aminophylline and terbutaline sulfate may improve the clinical status of patients with airway obstructive diseases and help in preventing respiratory muscle fatigue. Expand
Reversal of impaired calcium homeostasis in the rat diaphragm subjected to Monocrotaline-induced pulmonary hypertension.
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Pulmonary hypertension induced by MCT pneumotoxicity increased calcium uptake by the muscle cells in the rat diaphragm which may alter diaphagmatic contractility; an effect that was prevented by Indapamide. Expand

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