Interactions and associations of paraoxonase gene cluster polymorphisms with myocardial infarction in a Pakistani population.

@article{Saeed2007InteractionsAA,
  title={Interactions and associations of paraoxonase gene cluster polymorphisms with myocardial infarction in a Pakistani population.},
  author={Mohammad Saeed and Mohammad Perwaiz Iqbal and Farzana Abubakar Yousuf and Shehla Perveen and Mohsin Shafiq and Jamal Sajid and Philippe M. Frossard},
  journal={Clinical genetics},
  year={2007},
  volume={71 3},
  pages={238-44}
}
Polymorphisms of paraoxonase gene (PON) cluster have been investigated in numerous studies for their association with myocardial infarction (MI) but the results have been conflicting. Epistasis and gene-environment interactions at this locus could possibly modulate susceptibility toward MI and account for the discrepancies. We carried out a case-control study (211 MI patients and 370 control subjects) to test association of PON cluster polymorphisms with MI, their interactions with each other… CONTINUE READING
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