Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse

@article{Sanders1979InteractionsAT,
  title={Interactions among the cannabinoids in the antagonism of the abdominal constriction response in the mouse},
  author={Jill Sanders and David M. Jackson and Graham A. Starmer},
  journal={Psychopharmacology},
  year={1979},
  volume={61},
  pages={281-285}
}
The ability of Δ 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8α,11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective antagonist against all nociceptive agents with an ED50 in all cases between 1.0 and 2.6 mg/kg. CBN, while also effective against all nociceptive agents, was less potent than THC, with an ED50… CONTINUE READING