Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication foci.

@article{Park2006InteractionsAF,
  title={Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication foci.},
  author={Mi-Young Park and Young-Eui Kim and Myong-Rang Seo and Jae-Rin Lee and Chan Hee Lee and Jin-Hyun Ahn},
  journal={Journal of virology},
  year={2006},
  volume={80 6},
  pages={2718-27}
}
Four phosphoproteins, of 34, 43, 50, and 84 kDa, with common amino termini are synthesized via alternative splicing from the UL112-113 region of the human cytomegalovirus genome. Although genetic studies provided evidence that both the UL112 and UL113 loci in the viral genome are required for efficient viral replication, whether the four proteins play specific roles or cooperate in replication is not understood. Here we present evidence, using in vitro and in vivo coimmunoprecipitation assays… CONTINUE READING

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