Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance.

@article{Rescigno2008InteractionsAD,
  title={Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance.},
  author={Maria Rescigno and Uri A. Lopatin and Marcello Chieppa},
  journal={Current opinion in immunology},
  year={2008},
  volume={20 6},
  pages={669-75}
}
The intestine is described as an immune privileged site where immunoregulatory mechanisms simultaneously defend against pathogens, yet preserve tissue homeostasis to avoid immune-mediated pathology in response to environmental challenges. Additionally, tolerance to ingested antigens promotes the development of systemic unresponsiveness towards the same antigens. It is increasingly clear that this tolerance is a complex process that derives from the coordinated action of both canonical immune… CONTINUE READING