Interactions among HAMP domain repeats act as an osmosensing molecular switch in group III hybrid histidine kinases from fungi.

@article{Meena2010InteractionsAH,
  title={Interactions among HAMP domain repeats act as an osmosensing molecular switch in group III hybrid histidine kinases from fungi.},
  author={Netrapal Meena and Harsimran Jit Kaur and Alok Kumar Mondal},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 16},
  pages={
          12121-32
        }
}
The members of group III hybrid histidine kinases (HHK) are ubiquitous in fungi. Group III HHK have been implicated to function as osmosensors in the high osmolarity glycerol (HOG) pathway that is essential for fungal survival under high osmolarity stress. Recent literature suggests that group III HHK are also involved in conidia formation, virulence in several filamentous fungi, and are an excellent molecular target for antifungal agents. Thus, group III HHK constitute a very important group… CONTINUE READING
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HAMP Interactions Regulate NIK1 Orthologs 12132 JOURNAL OF BIOLOGICAL CHEMISTRY

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