Interactions Between Oral Contraceptives and Antifungals/Antibacterials

@article{Weisberg1999InteractionsBO,
  title={Interactions Between Oral Contraceptives and Antifungals/Antibacterials},
  author={Edith Weisberg},
  journal={Clinical Pharmacokinetics},
  year={1999},
  volume={36},
  pages={309-313}
}
  • E. Weisberg
  • Published 1 May 1999
  • Medicine, Biology
  • Clinical Pharmacokinetics
The effectiveness of oral contraceptives may be impaired by concomitant treatment with antimicrobials. This may occur because of reductions in plasma concentrations of ethinylestradiol by the induction of hepatic metabolism, as for rifampicin (rifampin) and possibly griseofulvin, or in a small percentage of women because of interference with enterohepatic recirculation.There are no scientific data to support the anecdotal evidence that the concomitant use of combined oral contraceptives and… 

Antibiotics and oral contraceptives.

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Based on previous studies, it is thought that the changes in trovafloxacin pharmacokinetics are secondary to induction or competition at cytochrome P-450 2C19 with the progestin components and/or an increase in phase II conjugation reactions by the estrogen components.

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Antibiotic Interference with Oral Contraceptives : Can a Dental Visit Make you Pregnant ?

  • Medicine
  • 2014
Dentists and physicians have been advised to warn female patients on oral contraceptives of a potential interaction with antibiotics and to advise additional forms of contraception when prescribing antibiotics, but scientific evidence has consistently and repeatedly failed to support such an interaction.

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This article summarises what is known of the drug-metabolising enzymes and transporters governing the metabolism, disposition and excretion ofα-Ethinylestradiol and related information to known clinical drug-drug interactions.

References

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Interactions with oral contraceptives

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  • Medicine, Biology
    American journal of obstetrics and gynecology
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Interactions between the oral contraceptive pill and antibiotics

The findings of this study would suggest that women who are receiving antibiotics and other conditions should be prescribed alternative forms of contraception.

Drug Interactions with Oral Contraceptives

  • P. D’arcy
  • Medicine, Biology
    Family planning information service
  • 1978
It is suggested that the effects of such interaction might be presented in terms of increased incidence of side effects, including water retention, diabetogenic effects, hypertension, and an increased risk of thromboembolic disorders.

Oral Contraceptives

It is suggested that all prescribers should remember to ask about OCs when taking a drug history and to consider the possibility of interactions with other drugs, as OCs have been shown to inhibit metabolism of many therapeutic drugs and increase their plasma concentrations.

Interaction between oral contraceptives and griseofulvin.

In the 22 patients the temporal relation between beginning griseofulvin and the occurrence of bleeding anomalies and the results of rechallenge with the drug in 4 patients are strong evidence of interaction between it and OCs, explaining the intermenstrual bleeding on the basis of a withdrawal effect but amenorrhea is not as easily explained.

Pharmacokinetic Drug Interactions with Oral Contraceptives

There is still no firm clinical pharmacokinetic evidence which indicates that blood concentrations of oral contraceptive steroids are altered by antibiotics, and perhaps this should not be a surprise, given that the incidence of the interaction may be very low.

Pregnancy-Associated with a Combined Oral-Contraceptive and Itraconazole

Although a causal relationship is unestablished additional contraceptive methods should be used by women taking oral contraceptives with itraconazole, the mechanism of action is unknown and it is probably unrelated to metabolism.

Oral contraceptive failure rates and oral antibiotics.

The effect of fluconazole on circulating ethinyl estradiol levels in women taking oral contraceptives.