Interactions Between Oral Contraceptives and Antifungals/Antibacterials

@article{Weisberg1999InteractionsBO,
  title={Interactions Between Oral Contraceptives and Antifungals/Antibacterials},
  author={E. Weisberg},
  journal={Clinical Pharmacokinetics},
  year={1999},
  volume={36},
  pages={309-313}
}
  • E. Weisberg
  • Published 1999
  • Medicine
  • Clinical Pharmacokinetics
The effectiveness of oral contraceptives may be impaired by concomitant treatment with antimicrobials. This may occur because of reductions in plasma concentrations of ethinylestradiol by the induction of hepatic metabolism, as for rifampicin (rifampin) and possibly griseofulvin, or in a small percentage of women because of interference with enterohepatic recirculation.There are no scientific data to support the anecdotal evidence that the concomitant use of combined oral contraceptives and… Expand
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Evaluation of interaction potential of certain concurrently administered drugs with pharmacological and pharmacokinetic profile of centchroman in rats.
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Evaluation of the effects of rifampicin, ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing estradiol valerate and dienogest in healthy postmenopausal women.
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Oral contraceptives are a safe and effective form of birth control used by millions of women in the United States and around the world. There have been anecdotal reports of unintended pregnanciesExpand
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TLDR
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Pharmacokinetic Drug Interactions Involving 17α-Ethinylestradiol
TLDR
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References

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Interactions with oral contraceptives.
TLDR
Evidence suggests that some anticonvulsant, antibiotic, and antibacterial drugs may reduce the efficacy of oral contraceptives and both pharmacokinetic and pharmacodynamic interactions are important. Expand
Interactions between the oral contraceptive pill and antibiotics
TLDR
The findings of this study would suggest that women who are receiving antibiotics and other conditions should be prescribed alternative forms of contraception. Expand
Possible interactions of antihistamines and antibiotics with oral contraceptive effectiveness.
In a private gynecology/obstetrics practice 16 patients taking oral contraceptives (OCs) between July 1978-July 1980 became pregnant. It was ascertained that none of the patients omitted any of theirExpand
Drug Interactions with Oral Contraceptives
  • P. D'arcy
  • Medicine
  • Family planning information service
  • 1978
TLDR
It is suggested that the effects of such interaction might be presented in terms of increased incidence of side effects, including water retention, diabetogenic effects, hypertension, and an increased risk of thromboembolic disorders. Expand
Oral Contraceptives
TLDR
It is suggested that all prescribers should remember to ask about OCs when taking a drug history and to consider the possibility of interactions with other drugs, as OCs have been shown to inhibit metabolism of many therapeutic drugs and increase their plasma concentrations. Expand
Interaction between oral contraceptives and griseofulvin.
TLDR
In the 22 patients the temporal relation between beginning griseofulvin and the occurrence of bleeding anomalies and the results of rechallenge with the drug in 4 patients are strong evidence of interaction between it and OCs, explaining the intermenstrual bleeding on the basis of a withdrawal effect but amenorrhea is not as easily explained. Expand
Pharmacokinetic Drug Interactions with Oral Contraceptives
TLDR
There is still no firm clinical pharmacokinetic evidence which indicates that blood concentrations of oral contraceptive steroids are altered by antibiotics, and perhaps this should not be a surprise, given that the incidence of the interaction may be very low. Expand
Pregnancy-Associated with a Combined Oral-Contraceptive and Itraconazole
TLDR
Although a causal relationship is unestablished additional contraceptive methods should be used by women taking oral contraceptives with itraconazole, the mechanism of action is unknown and it is probably unrelated to metabolism. Expand
Oral contraceptive failure rates and oral antibiotics.
TLDR
The difference in failure rates of OCs when taken concurrently with antibiotics commonly used in dermatology versus OC use alone suggests that these antibiotics do not increase the risk of pregnancy. Expand
The effect of fluconazole on circulating ethinyl estradiol levels in women taking oral contraceptives.
TLDR
Findings suggest that there is a potential for a clinically significant interaction between coadministration of fluconazole and ethinyl estradiol in oral contraceptives. Expand
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